Background. This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure\nrats induced by adenine. Methods. 32 adultmaleWistar rats were randomly divided into 4 groups fed normal diet, normal diet with\nquercetin supplementation (25mg/kg�BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation. All rats were\nsacrificed after 6 weeks of intervention. Serum renal functions biomarkers and oxidative stress biomarkers were measured and\nstatus of vascular calcification in aorta was assessed. Furthermore, the induced nitric oxide synthase (iNOS)/p38mitogen activated\nprotein kinase (p38MAPK) pathway was determined to explore the potential mechanism. Results. Adenine successfully induced\nrenal failure and vascular calcification in rat model. Quercetin supplementation reversed unfavorable changes of phosphorous,\nuric acid (UA) and creatinine levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity in serum and the\nincreases of calcium and alkaline phosphatase (ALP) activity in the aorta (
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